Bone Pain in Multiple Myeloma (BPMM)—A Protocol for a Prospective, Longitudinal, Observational Study

Multiple myeloma (MM) is a bone marrow neoplasia that causes pain in 70% patients. While preclinical models of MM have suggested both nerve sprouting and injury may be causative for the pain, there lack clinical data. Thus, primary aims this study are: (1) to provide deep characterization subjective experience quality life patients; (2) investigate disturbances innervation Secondary include exploring correlations between serum inflammatory turnover biomarkers. In prospective, observational (clinicaltrials.gov: NCT04273425), patients with suspected requiring diagnostic iliac crest biopsy at Sheffield Teaching Hospital (UK) are invited participate. Consenting answer seven standardized questionnaires assessing catastrophizing. Bone biomarkers cytokines measured fasting samples, evaluated biopsies. follow-up upon completion first line treatment. This will its correlation innervation. Understanding how inflammation correlate crucial identify novel analgesic targets condition.